Table 3.

Identified BACE1 substrate-cleavage sites

Substrate	Cleavage site	Reference
APP wild type	SEVKM671 ↓ D672AEFR	66
APP Swedish mutant	SEVNL671 ↓ D672AEFR	66
APLP-2	IDETL659 ↓ D660VKEM	175
Nrg1 type Iβ1	LGIEF237 ↓ M238EAEE	149
PSGL-1	ISVKQ335 ↓ A336ASNL	185
VGSC β2	HLQVL147 ↓ M148EEPP	164
IL1-R2	NTLSF329 ↓ Q330TLRT	186

Abbreviations: BACE-1, β-site amyloid precursor protein-cleaving enzyme; APP, amyloid precursor protein; APLP, amyloid precursor-like protein; Nrg, neuregulin; PSGL, P-selectin glycoprotein ligand-1; VGSC, voltage-gated sodium channel; IL1-R2, interleukin-1 receptor 2.