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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Neurobiol Dis. 2020 May 15;141:104944. doi: 10.1016/j.nbd.2020.104944

Figure 7:

Figure 7:

Metabolic changes in ON from OHT mice injected with AAV2:MCT2. A. The ratio of phosphorylated AMP kinase (pAMPK) to AMPK is significantly lower in OHT mice injected with AAV2:MCT2 (n=5) compared to control mice (no OHT or virus, n=6) and OHT mice injected with AAV2:GFP (n=6; p<0.01, p<0.05 respectively). B. PGC-1α protein in ON did not differ statistically across groups. ON sample number was n=12 for the No OHT, No AAV2 group, n=3 for the Control AAV+MCT2 group, and n=4 for the AAV2:MCT2+OHT group. C. Hexokinase activity is significantly decreased in OHT mice injected with AAV2:MCT2 (n=3) compared to OHT mice alone (n=4; p<0.05). ON sample number was n=3 for the No OHT, No AAV2 group, and n=5 for the OHT Control AAV2 group. D. Mitochondria size and E. Mitochondria density in the ganglion cell layer (GCL) did not differ across the Control AAV2+OHT (n=24 retinal sections across 3 mice) and AAV2:MCT2+OHT (n=22 retinal sections across 3 mice) groups. Error bars are SD.