TABLE 3.
Top 20 Most Affected Biological Processes According to Gene Ontology Analysis Based on Sets of Statistically Significant Downregulated Genes on Day 6, High Dose vs. 0 Dose
| GO biological process complete | Padj value |
|---|---|
| Nervous system development | 1.27E–32 |
| Neurogenesis | 1.92E–25 |
| Anatomical structure morphogenesis | 9.89E–25 |
| Generation of neurons | 1.79E–24 |
| Anatomical structure development | 4.05E–24 |
| Developmental process | 1.72E–23 |
| Multicellular organism development | 1.95E–23 |
| System development | 3.74E–23 |
| Plasma membrane bounded cell projection organization | 6.61E–23 |
| Central nervous system development | 1.00E–22 |
| Cell projection organization | 1.64E–22 |
| Head development | 1.49E–21 |
| Brain development | 7.34E–21 |
| Neuron differentiation | 6.27E–20 |
| Sensory organ development | 6.56E–18 |
| Cellular developmental process | 5.36E–17 |
| Regulation of cellular process | 5.39E–17 |
| Regulation of transcription by RNA polymerase II | 8.10E–17 |
| Regulation of biological process | 3.50E–16 |
| Cell differentiation | 3.96E–16 |
Note. The processes directly related to neural differentiation are indicated in bold face.