Table 3. Change in IOP and ONH characteristics of participants with and without trabeculectomy.
One-time interval contained the trabeculectomy (with optical coherence tomography measurements prior to and following the surgery). Two time intervals did not contain the trabeculectomy.
| Change during interval containing trabeculectomy (95% CI) |
Change during intervals not containing trabeculectomy (95% CI) |
P-value comparing intervals with and without trabeculectomy |
|
|---|---|---|---|
| Intraocular pressure (mmHg) | −9.2 (−11.7 to −6.8) p < 0.001 |
+0.2 (−1.1 to +1.4) p = 0.814 |
<0.001 |
| Retinal Nerve Fiber Layer Thickness (μm) | −2.01 (−3.72 to −0.29) p = 0.033 |
−0.74 (−1.64 to +0.17) p = 0.119 |
.375 |
| Minimum Rim Width (μm) | +6.04 (+0.2 to +11.9) p = 0.057 |
−4.43 (−7.38 to −1.47) p = 0.006 |
0.001 |
| Minimum Rim Area (mm2) | +0.014 (−0.011 to +0.040) p = 0.283 |
−0.021 (−0.043 to +0.002) p = 0.083 |
0.024 |
| Angle above reference plane of Minimum Rim Width (°) | +2.64 (+1.00 to +4.29) p = 0.005 |
−0.74 (−1.53 to +0.04) p = 0.072 |
<0.001 |
| Angle above reference plane of Minimum Rim Area (°) | +1.16 (−0.29 to +2.61) p = 0.133 |
−0.19 (−0.99 to +0.62) p = 0.656 |
0.113 |
| Bruch’s Membrane Opening Area (mm2) | −0.034 (−0.075 to +0.008) p = 0.126 |
−0.01 (−0.05 to +0.03) p = 0.625 |
0.292 |
| Mean Cup Depth (μm) | −11.6 (−22.8 to −0.4) p = 0.057 |
−1.0 (−3.3 to +1.3) p = 0.411 |
0.007 |
| Mean Anterior Lamina Cribrosa Surface Depth (μm) | −18.91 (−37.38 to −0.43) p = 0.059 |
−0.02 (−5.24 to +5.20) p = 0.995 |
0.006 |
| Prelaminar Tissue Thickness (μm) | 13.2 (−5.4 to +31.9) p = 0.179 |
−5.5 (−16.1 to +5.1) p = 0.319 |
0.131 |
| Mean Deviation (dB) | −0.26 (−0.98 to +0.45) p = 0.478 |
−0.22 (−0.80 to +0.36) p = 0.459 |
0.972 |
| Pattern Standard Deviation (dB) |
−0.2 (−1.1 to +0.7) p = 0.633 |
+0.4 (+0.0 to +0.7) p = 0.042 |
0.150 |
| Visual Field Index (%) | −0.9 (−3.2 to +1.4) p = 0.445 |
−0.2 (−1.9 to +1.5) p = 0.823 |
0.661 |
Confidence intervals and p-values are from generalized least squares models adjusting for the presence of multiple time points and fellow eyes. P-values in the first two columns represent the significance of the change against zero.