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Histopathological features of nodal EBV+ cytotoxic T-cell lymphoma (CTL). (A) Nodal EBV+ CTL is characterized by a centroblastoid appearance, morphologically resembling diffuse large B-cell lymphoma. (B) In contrast, nasal-type NK/T-cell lymphoma is characterized by pleomorphic and elongated nuclei. (C and D) In nodal EBV+ CTL, the tumor cells are positive for granzyme B (C) and CD8 (D). (E) EBV is detected by in-situ hybridization.
