Table 2. Structural characteristics of the studied groups.
| Parameter | Healthy | Mild POAG | Moderate/Severe POAG | P Values† | ||
|---|---|---|---|---|---|---|
| Mild vs Healthy | Moderate/ Severe vs Healthy | Moderate/ Severe vs Mild | ||||
| Optical CoherenceTomographyAngiography | ||||||
| SVP whole VD (%) | 49.7±2.6) | 42.9±5.2 | 38.7±6.3 | 0.001 | <0.001 | 0.002 |
| SVP superior-hemi VD (%) | 50.2±3 | 43.3±5.3 | 39.1±6.1 | 0.001 | <0.001 | 0.003 |
| SVP interior-hemi VD (%) | 49.6±2.7 | 42.5±5.2 | 38.4±6.6 | <0.001 | <0.001 | 0.003 |
| SVP parafovea VD (%) | 52.4±4.1 | 46.9±5.9 | 43.6±6.1 | 0.015 | <0.001 | 0.018 |
| DVP whole VD (%) | 49.3±3.4 | 47.8±5.7 | 46.9±5.5 | 0.976 | 0.571 | 0.504 |
| DVP/SVP VD index | 1.±0.1 | 1.1±0.1 | 1.2±0.1 | 0.001 | <0.001 | 0.011 |
| SQ Macula index | 8(7–8)* | 7(7–8)* | 7(7–8)* | 0.208 | 0.162 | 0.782 |
| pRPC VD (%) | 51.2±2.9 | 43.6(6.6) | 36.2±7.2 | 0.001 | <0.001 | <0.001 |
| RPC whole VD (%) | 49.1±2.4 | 42.7±5.6 | 36.4±5.7 | 0.001 | <0.001 | <0.001 |
| RPC superior-hemi VD (%) | 51.4±3.2 | 44.1±6.6 | 37.2±7.1 | 0.001 | <0.001 | 0.001 |
| RPC inferior-hemi VD (%) | 51.1±2.9 | 43.1±6.9 | 35.1±8.1 | 0.001 | <0.001 | <0.001 |
| SQ OpticDisc index | 9(8–9)* | 8(7–9)* | 8(8–9)* | 0.124 | 0.401 | 0.521 |
| Spectral Domain Optical Coherence Tomography | ||||||
| GCC average (μm) | 98.2±9.8 | 82.3±10.9 | 71.6±11.3 | <0.001 | <0.001 | 0.001 |
| GCC superior (μm) | 97.4±1 | 82.7±11 | 71.6±10.8 | <0.001 | <0.001 | 0.001 |
| GCC inferior (μm) | 99.1±9.8 | 82.2±11.2 | 71.6±12.2 | <0.001 | <0.001 | 0.001 |
| pRNFLglobal (μm) | 101.8±10.3 | 78.8±13.9 | 61.4±14.2 | <0.001 | <0.001 | <0.001 |
| pRNFL superior (μm) | 122.4±12.2 | 97.4±17.9 | 74.6±20.2 | <0.001 | <0.001 | <0.001 |
| pRNFLinferior (μm) | 131±18.1 | 98.7±22.2 | 69.2±25.1 | <0.001 | <0.001 | <0.001 |
| pRNFLtemporal (μm) | 72.4±17.6 | 57±15.9 | 49.4±11.9 | 0.003 | <0.001 | 0.094 |
| pRNFLnasal (μm) | 81.6±11.7 | 62.1±15.2 | 52.2±15.6 | <0.001 | <0.001 | 0.027 |
Mean (standard deviation).
*Median (interquartilerange).
†P Values adjusted for age, inter-eye correlation and SQ (in OCTA), based on Linear Mixed Effects Model.
Abbreviations: POAG = primary open-angle glaucoma; SQ = scan quality; SVP = superficial vascular plexus; DVP = deep vascular plexus; p- = peripapillary; RPC = radial peripapillary capillaries; VD = vessel density; GCC = ganglion cell complex; RNFL = retinal nerve fiber layer; OCTA = optical coherence tomography angiography.