Fig 3. 2062 and rifampin reduce the bacterial burden and histopathology in Mtb-infected mice.

Mice were infected with Mtb by inhalation and disease was allowed to develop for 2 weeks. (A) Treatment was by oral gavage for 6 weeks beginning on day 15, followed by plating of lungs for CFU. Mice were treated with vehicle alone (solid black circles); with 2062 alone at 30 mg/kg (solid blue circles) or 50 mg/kg (solid purple circles); or with rifampin at 3 mg/kg (open circles) given alone or together with the indicated doses of 2062. P values calculated by the unpaired t-test. (B) Immunopathology scores of lung slices from mice in (A) treated with 30 mg/kg 2062 alone or in combination with 3 mg/kg rifampin. Score numbers reflect the extend of inflammatory lesions: 0, no lesions; 1, minimal inflammation; 2, mild inflammation; 3, moderate inflammation; 4, marked inflammation.