Table 1.

Risk of COVID-19 Test Positivity and Mortality, Comparing Participants With ApoE e3e4 or e4e4 to e3e3 Genotypes, in UK Biobank

							COVID-19 Positive vs Rest of Study Sample		COVID-19 Positive and Died vs Rest^† of Study Sample
	n	Negative or Untested	Positive	Positive and Dead	Positivity Rate per 10⁵	Positivity and Death Rate per 10⁵	OR (95% CI)*	p Value	OR (95% CI)*	p Value
All
e3e3	219 747	219 084	663	79	302	36
e3e4	88 882	88 561	321	42	361	47	1.20 (1.05, 1.37)	.009	1.35 (0.92, 1.96)	.121
e4e4	8767	8708	59	13	673	148	2.24 (1.72, 2.93)	3.24E-9	4.29 (2.38, 7.72)	1.22E-6
Excluding dementia
e3e3	219 392	218 744	648	76	295	35
e3e4	88 558	88 263	295	34	333	39	1.13 (0.98, 1.29)	.093	1.14 (0.76, 1.70)	.536
e4e4	8676	8618	58	13	669	151	2.27 (1.74, 2.98)	2.42E-9	4.53 (2.51, 8.16)	5.21E-7
Excluding hypertension
e3e3	147 332	146 958	374	31	254	21
e3e4	59 655	59 483	172	17	288	29	1.13 (0.94, 1.35)	.186	1.39 (0.77, 2.51)	.278
e4e4	5918	5881	37	5	625	85	2.45 (1.75, 3.44)	2.10E-7	4.25 (1.65, 10.95)	.003
Excluding coronary artery disease
e3e3	201 003	200 435	568	62	283	31
e3e4	80 850	80 590	260	33	322	41	1.14 (0.98, 1.32)	.090	1.36 (0.89, 2.08)	.153
e4e4	7973	7923	50	10	627	126	2.23 (1.67, 2.98)	6.21E-8	4.23 (2.16, 8.26)	2.43E-5
Excluding type 2 diabetes
e3e3	208 374	207 795	579	61	278	29
e3e4	84 620	84 342	278	30	329	36	1.18 (1.02, 1.36)	.024	1.24 (0.80, 1.92)	.338
e4e4	8 391	8336	55	12	655	144	2.36 (1.79, 3.12)	1.23E-9	5.05 (2.72, 9.39)	3.08E-7

Notes: CI = confidence interval; OR = odds ratio.

*Adjusted for sex, age at death or age on April 26, 2020 (the last date of death), assessment center in England, genotyping array type, and the top five genetic principal components.

^†Comparison group excluded participants testing positive and surviving.