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. 2020 Jun 21;222(5):734–745. doi: 10.1093/infdis/jiaa356

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© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

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Figure 5. — SARS-CoV-2 induced significant proinflammatory response in MDMs but not moDCs. MoDCs (A) and MDMs (B) were inoculated with SARS-CoV-2 or SARS-CoV at an MOI of 1. The cell lysates were harvested for qRT-PCR analysis of representative proinflammatory cytokines and chemokines. The results represent mean and standard deviations from 3 to 6 individual donors in 3 independent experiments. Statistical significance between the groups was determined with 2-way ANOVA and was consider significant when P < .05. * P < .05, ** P < .01. Abbreviations: MOI, multiplicity of infection; TNF-α, tumor necrosis factor-α; IP-10, IFN-γ inducible protein-10; MCP-1, monocyte chemoattractant protein-1; MIP-1α, macrophage-inflammatory protein-1α; RANTES, regulated upon activation normal T-cell expressed and secreted; moDCs, monocyte-derived dendritic cells; MDMs, monocyte-derived macrophages; qRT-PCR, quantitative reverse transcription polymerase chain reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.