Figure 4.

HrrA prioritizes the expression of genes encoding components of the bc₁–aa₃ supercomplex. Depicted are HrrA binding peaks as identified by ChAP-Seq analysis (Figures 1 and 2) in comparison to the normalized coverage of RNA-Seq results (wild-type and the ΔhrrA mutant) for the genomic loci of ctaE (A andD), sigC (B andE) and cydA (C andF). D–F: HrrA binding (max. peak intensities measured by ChAP-Seq experiments) and the mRNA levels (in transcripts per million, TPM) of the respective genes in the ΔhrrA strain as well as in wild-type Corynebacterium glutamicum cells 0, 0.5 and 4 h after the addition of hemin.