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. 2020 May 28;48(12):e69. doi: 10.1093/nar/gkaa398

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — (A) PolyA-miner reveals extensive 3′UTR shortening in LN299 Glioblastoma NUDT21 knock down data: Size of the marker indicate statistical significance. Color gradient (red to orange) indicate 3′UTR length long to short. (B) Overlap and discordance of PolyA-miner and DPU predictions. (C) APA heatmap of genes with two polyadenylations that are predicted to be 3′UTR shortening only by PolyA-miner. (D) NUDT21 motif frequency in genes that are predicted to be 3′UTR shortening by PolyA-miner. (E) Phenotype analysis of PolyA-miner results. (F) Clustering stability of PolyA-miner and DPU only predictions. (G and H) Tracks showing 3′UTR shortening identified by both PolyA-miner and DPU, and only PolyA-miner. (I and J) APA proportion matrices of the genes shown in (G) and (H) respectively.