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Experimental scheme and sample cohorts. (A) Homogenous samples of corneal endothelium are surgically removed from normal, presymptomatic and, affected (FECD or FECD_NR) tissue bank donors or patients and used for RNAseq followed by data analysis. (B) Detailed description of tissue samples. (C) Dendrogram for four groups of samples and (D) all replicates. RIN:RNA integrity number. CTG18.1: the number of repeats on each chromosome.
