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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Curr Opin Neurol. 2020 Jun;33(3):277–285. doi: 10.1097/WCO.0000000000000818

Figure 3. Demyelinated brain lesion distribution on postmortem MRI in progressive MS.

Figure 3.

The case is a 59-year old man with progressive MS, EDSS 6.5 and 21 years of disease duration (treated with IFNß-1a between ages 49–51). Postmortem MRI scans (gradient echo sequence) of the formalin-fixed brain shows extensive cortical demyelination (yellow asterisks), especially in the depth of the sulci and the hippocampi, and confluent chronic active/slowly expanding lesions (periventricular and leukocortical; red asterisks). Some demyelinated lesions are seen also within the thalamus.