HS compositional analysis in normal and patient plasma samples. Panel 1. major disaccharides of patient showing significant differences compared to normal human, Panel 2. minor disaccharides showing less significant differences. A. Heparan sulfate disaccharides without sulfation (0S), B. NS, C. 6S, D. NS2S, E. NS6S, F. TriS, G.2S, H. 2S6S.