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. Author manuscript; available in PMC: 2020 Jul 6.
Published in final edited form as: J Pain. 2018 Nov 22;20(5):528–539. doi: 10.1016/j.jpain.2018.11.001

Figure 2.

Figure 2.

The effect of early repeated application of retigabine on the development of chronic behavioral hypersensitivity and spontaneous pain after paclitaxel. (A) Timeline for the experiments. (B) Mechanical hypersensitivity of hindpaws was measured 12, 28, and 35 days after initial paclitaxel treatment. Dots in columns represent one animal each. Repeated measures two-way ANOVA followed by Sidak’s multiple comparison test (treatment F(1, 9) = 21.58, p = 0.0012; time F(3, 27) = 34.16, p < 0.0001; interaction F(3, 27) = 4.546, P = 0.0105. Baseline, P > 0.999; 12 days, P = 0.0024; 28 days, P = 0.0014; 35 days, P = 0.0006. (C) Conditioned place preference tests were performed 4 weeks after treatment. Dots in each column represent individual rats tested in each condition. P = 0.039, F(2, 16) = 4.0, One-way ANOVA, Pacli, paclitaxel; retig, retigabine. *, p<0.05.