Table 1.
Selected ventilatory characteristics of critically ill patients with COVID-19
| Italy9 | Seattle, WA, USA33 | Italy34 | Boston, MA, USA2 | Amsterdam3 | New York City, NY, USA5 | New York City, NY, USA4 | ||
|---|---|---|---|---|---|---|---|---|
| Number of patients | 16 | 24 | 1300 | 66 | 38 | 257 | 267 | |
| Respiratory support* | ||||||||
| Invasive mechanical ventilation | 16 (100%) | 18 (75%) | 1150 (88%) | 66 (100%) | 38 (100%) | 203 (79%) | 267 (100%) | |
| Non-invasive ventilation | 0 | 0 | 137 (11%) | 1 (2%) | 0 | 3 (1%) | 51 (19%) | |
| HFNC | 0 | 10 (42%) | 0 | 1 (2%) | 0 | 12 (5%) | 0 | |
| PaO2/FiO2 ratio | .. | 142 (94–177) | 160 (114–220) | 182 (135–245) | 132 (48)† | 129 (80–203) | 103 (82–134) | |
| Compliance, mL/cm H2O | 50 (14·3)† | 29 (25–36) | .. | 35 (30–43) | 49 (24)† | 26 (21–38) | 28 (23–38) | |
| Plateau pressure, cm H2O | .. | 25 (20–28) | .. | 21 (19–26) | 21 (7–23) | 27 (22–31) | 25 (21–29) | |
| PEEP, cm H2O | .. | .. | 14 (12–16) | 10 (8–12) | 10 (9–12) | 15 (12–18) | 10 (8–12) | |
| Tidal volume, mL/kg PBW | .. | .. | .. | .. | .. | 6·2 (5·9–7·2) | 7·0 (6·1–8·1) | |
| FiO2 | .. | 90% (70–100) | 70% (50–80) | .. | .. | 100% (80–100) | .. | |
| Prone positioning | Not reported | 5/18‡ (28%) | 240/875§ (27%) | 31 (47%) | Not reported | 35 (17%) | 108 (40%) | |
| ECMO | Not reported | 0 | 5/498§ (1%) | 3 (5%) | Not reported | 7 (3%) | Not reported | |
Data are n (%) or median (IQR), unless otherwise indicated. ECMO=extracorporeal membrane oxygenation. FiO2=fraction of inspired oxygen. HFNC=high-flow nasal cannula. PaO2=partial pressure of arterial oxygen. PBW=predicted bodyweight. PEEP=positive end-expiratory pressure.
*
Some patients received more than one type of respiratory support.
†
Mean (SD).
‡
Denominator is 18 for the group that had invasive mechanical ventilation.
§
It is not explicitly stated in the manuscript why the denominators are different, although they might represent the group of patients for which these data were collected and available at the time of analysis.