Figure 1. Concentrations of human Aβ species are similar in the CSF of peri-adolescent Trem2^w/w, Trem2^R47H/w, and Trem2^R47H/R47H rats.

Levels of Aβ38, Aβ40, and Aβ42/Aβ40 ratio in 6–8 weeks old Trem2^w/w, Trem2^R47H/w, and Trem2^R47H/R47H rat CSF. We used the following numbers of samples: Trem2^w/w, females n = 12, males n = 16; Trem2^R47H/w females n = 6, males n = 10; Trem2^R47H/R47H females n = 10, males n = 17. Data are represented as mean ± SEM. Data were analyzed by ordinary one‐way ANOVA. No differences were seen in Aβ38 [F_{(2, 68)}=0.5339, p=0.5887], Aβ40 [F_{(2, 68)}=1.010, p=0.3696], Aβ42 [F_{(2, 68)}=0.4376, p=0.6474] levels and the Aβ42/Aβ40 ratio [F_{(2, 68)}=1.564, p=0.2168].