Fig. 2.

Protein abundance in patients with mitral valve regurgitation retrieves highly abundant gene candidates in GWAS loci previously associated with mitral valve prolapse. For genes located in GWAS loci associated with mitral valve prolapse, we retrieved protein intensity measurements from left atrium from patients with mitral valve prolapse (points: single measurements of normalized protein intensities, bars: median). For each locus, high protein abundance singled out 1–2 gene candidates significantly higher expressed in the left atrium, the tissue where the disease manifests. (gene names highlighted in bold, p values: two-sided Student's t test p values). GWAS: Genome-wide association study, MS: mass spectrometry. Proteomics data based on biopsy measurements of seven individuals: 7 RA biopsies, 6 LA biopsies, 7 LV biopsies are underlying this analysis.