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. 2020 Jul 6;30(8):708–710. doi: 10.1038/s41422-020-0369-7

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© Center for Excellence in Molecular Cell Science, CAS 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a H&E staining of the lungs of two COVID-19 patients. b Immunostaining using antibodies against proSPC, Ki67, and HTI-56 of a healthy donor lung and lungs of two COVID-19 patients. c–e′ Immunostaining using antibodies against HTII-280 and SFN (c), HTII-280 and CLDN4 (d), and HTII-280 and KRT8 (e) of a healthy donor lung and the COVID-19 lungs. The percentage of intermediate AT2 cells in total AT2 cells were quantified (c′, d′, and e′). f TEM images of the COVID-19 lungs. The red dashed line indicates the location of the basement membrane. Scale bars, 100 µm (a), 20 µm (b–e), 5 µm (f).