Table 3. The relationship between elevated ALT levels and the development of gestational diabetes/preeclampsia, analyzed by multiple logistic regression analysis with backward elimination after adjustment for maternal age, pre-pregnancy BMI, AST, cholesterol, and alkaline phosphatase.
| Variables | Adjusted OR | 95% CI | P value | |
|---|---|---|---|---|
| Gestational diabetes according to WHO criteria | ||||
| Elevated ALT levels, > 95th percentile | 2.416 | 1.048–5.572 | < 0.05 | |
| Old maternal age, > 35 yr | 1.925 | 1.067–3.473 | < 0.05 | |
| Pre-pregnancy BMI, > 30 kg/m2 | 1.883 | 1.161–3.053 | < 0.05 | |
| Cholesterol | 1.015 | 1.006–1.023 | < 0.005 | |
| Gestational diabetes according to IADPSG criteria | ||||
| Elevated ALT levels, > 95th percentile | 1.795 | 1.002–3.217 | < 0.05 | |
| Old maternal age, > 35 yr | 1.528 | 1.093–2.137 | < 0.05 | |
| Pre-pregnancy BMI, > 30 kg/m2 | 1.761 | 1.301–2.382 | < 0.001 | |
| Cholesterol | 1.008 | 1.003–1.014 | < 0.005 | |
| Preeclampsia | ||||
| Elevated ALT levels, > 95th percentile | 3.242 | 1.057–8.406 | < 0.05 | |
| Pre-pregnancy BMI, > 30 kg/m2 | 3.159 | 1.745–5.473 | < 0.001 | |
OR = odds ratio, CI = confidence interval, ALT = alanine aminotransferase, WHO = World Health Organization, BMI = body mass index, IADPSG = International Association of Diabetes and Pregnancy Study Groups, AST = aspartate aminotransferase.