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. Author manuscript; available in PMC: 2020 Jul 6.
Published in final edited form as: Nat Immunol. 2019 Dec 16;21(1):86–100. doi: 10.1038/s41590-019-0549-0

Figure 1. Variation in immune cell subset composition with sex as a contributory driver.

Figure 1

a. Overview of the tests performed by WTSI as part of IMPC (inner circle) and by 3i and WTSI as part of 3i (outer circle).

b. Sexual dimorphism in the immune system: Population sizes as % of CD45 cells (upper panel); sexual dimorphism of mean values of population sizes as log2 fold change (middle panel, female/male); and % coefficient of variation (lower panel) of immune populations in SPL, BM and PB from 16-week old male and female wt C57BL/6N mice (n>500). Blue arrows denote cell subsets mentioned in text. Blue and orange circles in bottom panel denote CV values for female and male mice, respectively. Non adjusted p-values from two-sided Wilcoxon test.

c. Left: Neutrophils from peripheral blood of 16-week old wt C57BL/6N mice (for females n=918 and for males n=913, bars represent means) Right: Hardy fractions A and C from the bone marrow of 16-week old WT C57BL/6N mice (for females n=308, for males n=315, bar represents mean)

d. PCA of cell type frequencies from four tissues (SPL, MLN, BM, PB), 60 subsets, and 451 mice; colour denotes sex.