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. Author manuscript; available in PMC: 2020 Jul 6.
Published in final edited form as: Nat Immunol. 2019 Dec 16;21(1):86–100. doi: 10.1038/s41590-019-0549-0

Figure 5. Examples of genes with specific impacts on the immune system.

Figure 5

a. Overview of two genes that display specific immunophenotypes. Colours as in Fig 4. Statistical methods and sample size differ between parameters – see Materials and Methods and www.immunophenotype.org for specific gene/parameter combination of n.

b. Vγ5 DETC in ear epidermis of wt and Nacc2–/–mice. The image represents a z-projection of cell outlines produced by image processing in Definiens Developer XD, which were used for quantitative object-based image analysis: blue, Langerhans cells (LC); red, Vγ5+ DETC contacting LC; green, Vγ5+ DETC not contacting LC. Bottom: cumulative data for Nacc2–/–mice (n=4) versus sex-matched wt controls (for females n=330, for males n=340, bar represents mean).

c. Phenotypic abnormalities in Dph6–/– mice. Fold change in immune cell subset proportions between Dph6–/– and wt mice across multiple tissues (Dph6–/–, n=6 for SPL, MLN, BM and n=14 for PBL; wt, n>500 for all parameters).