Skip to main content
. Author manuscript; available in PMC: 2020 Jul 6.
Published in final edited form as: Nat Immunol. 2019 Dec 16;21(1):86–100. doi: 10.1038/s41590-019-0549-0

Figure 6. Examples of genes that impact upon the immune system and physiology.

Figure 6

a. Overview of two genes that exhibit broad immunophenotypes. Colours as in Fig 4. Statistical methods and sample size differ between parameters – see Materials and Methods and www.immunophenotype.org for specific gene/parameter combination of n.

b. Phenotypic abnormalities PBL in Duoxa2–/– mice. Relative PBL cell subset frequencies for Duoxa2–/– (n=11) versus wt mice (n>450 per sex for all parameters). Dark and light blue denote wt males and females; red and orange denote Duoxa2–/– males and females.

c. Effector cell subsets in Bach2–/– mice. Fold-change in SPL cell subset composition in mutant mice (n=6) versus wt controls (n=76). Yellow represents significant cellular phenotypes not previously reported, as detected by reference range; dark blue represents significant cellular phenotypes previously reported; light blue represents non-significant differences. KLRG1+CD4- NK cells: 10-fold increase, p=1.1x10-9; reference range combined with Fisher’s exact test).

d. Cytotoxic T lymphocytes in Bach2–/– mice (n=4) compared to wt controls (212 female and 208 male): grey points represent individual wt mice; red circles represent individual Bach2–/– mice.

e. DSS colitis in Bach2–/– mice (n=4) compared to wt controls (n=481 female and n=315male): grey points represent individual wt mice; white circles represent wt mean values; blue circles represent individual Bach2–/– mice.