Table 1.
Distribution of the BC risk factors related to familial history (Group 1) in the KBCP dataset.
| Feature names | Cases (N = 445) | Controls (N = 250) | All subjects (N = 695) | Feature description | p-value | |
|---|---|---|---|---|---|---|
| Cancer in family | 0 | 196 (44%) | 136 (54%) | 332 (48%) | Whether there is any cancer in family members: 0: No; 1: Yes | 0.01 |
| 1 | 249 (56%) | 114 (46%) | 363 (52%) | |||
| Cancer type 1 | 0 | 394 (89%) | 235 (94%) | 629 (90%) | Type of cancer in the 1st family member with cancer: 0: Other; 1: Breast | 0.02 |
| 1 | 51 (11%) | 15 (6%) | 66 (10%) | |||
| Cancer type 2 | 0 | 437 (98%) | 249 (99%) | 686 (99%) | Type of cancer in the 2nd family member with cancer: 0: Other; 1: Breast | 0.2 |
| 1 | 8 (2%) | 1 (1%) | 9 (1%) | |||
| First-degree relative 1 | 0 | 398 (89%) | 238 (95%) | 636 (91%) | whether the 1st family member with breast cancer is a first-degree relative: 0: No; 1: Yes | 0.01 |
| 1 | 47 (11%) | 12 (5%) | 59 (9%) | |||
| First-degree relative 2 | 0 | 438 (98%) | 249 (99%) | 687 (99%) | whether the 2nd family member with breast cancer is a first-degree relative: 0: No; 1: Yes | 0.3 |
| 1 | 7 (2%) | 1 (1%) | 8 (1%) | |||
| No. of BCs | 0 | 393 (88%) | 235 (94%) | 628 (90%) | Number of family members with BC. | 0.04 |
| 1 | 45 (10%) | 14 (5%) | 59 (9%) | |||
| 2 | 7 (2%) | 1 (1%) | 8 (1%) | |||
| BC risk score | 0 | 396 (89%) | 238 (95%) | 634 (91%) | Number of first-degree family members with BC. | 0.02 |
| 1 | 44 (10%) | 11 (4%) | 55 (8%) | |||
| 2 | 5 (1%) | 1 (1%) | 6 (1%) | |||
| Lateral 1 | 0 | 394 (88%) | 235 (94%) | 629 (90%) | Whether the 1st family member has unilateral or bilateral BC: 0: No tumour; 1: Unilateral; 2: Bilateral | 0.06 |
| 1 | 48 (11%) | 14 (5%) | 62 (9%) | |||
| 2 | 3 (1%) | 1 (1%) | 4 (1%) | |||
| Lateral 2 | 0 | 437 (97%) | 249 (99%) | 686 (97%) | Whether the 2nd family member has unilateral or bilateral BC: 0: No tumour; 1: Unilateral; 2: Bilateral | 0.2 |
| 1 | 7 (2%) | 1 (1%) | 8 (2%) | |||
| 2 | 1 (1%) | 0 (0%) | 1 (1%) | |||
The P-values denote the differences in the Group 1 features between the BC cases and controls using the chi-squared test for categorical variables. The difference is statistically significant when the p-value < 0.05 (highlighted p-values). P-values were not adjusted for multiple testing.