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. 2020 Jul 6;11:3368. doi: 10.1038/s41467-020-17002-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The X axis shows the count of genes from tissues in the GTEx database meeting significance thresholds for multiple testing for migraine and for each of the BP measures as indicated. The Y axis lists GTEx tissues. Colors represent different tissue categories. The null hypothesis of TWAS is no expression-trait association (or genetic correlation between expression and a trait) conditional on the observed GWAS statistics at the corresponding locus. The total number of TWAS gene-tissue pairs being tested is 206,397 across 48 GTEx tissues. TWAS transcriptome-wide association studies, BP blood pressure, DBP diastolic blood pressure, SBP systolic blood pressure, PP pulse pressure, No. number.