Table 1.
Method | Trait 1 | Trait 2 | rg | P* | gcov | gcov_se |
---|---|---|---|---|---|---|
LDSC | Any migraine | DBP | 0.11 | 3.56 × 10−06 | 0.018 | 0.009 |
SBP | 0.06 | 0.01 | 0.004 | 0.009 | ||
PP | −0.01 | 0.75 | −0.009 | 0.008 | ||
Migraine with aura | DBP | 0.17 | 1.50 × 10−03 | −0.006 | 0.008 | |
SBP | 0.10 | 0.04 | −0.014 | 0.008 | ||
PP | 0.00 | 0.92 | −0.015 | 0.007 | ||
Migraine without aura | DBP | 0.14 | 1.20 × 10−03 | 0.014 | 0.008 | |
SBP | 0.03 | 0.43 | 0.010 | 0.008 | ||
PP | −0.08 | 0.06 | 0.002 | 0.007 | ||
GNOVA | Any migraine | DBP | 0.12 | 3.45 × 10−07 | 0.009 | 0.002 |
SBP | 0.07 | 4.64 × 10−03 | 0.005 | 0.002 | ||
PP | 0.00 | 0.94 | 0.000 | 0.002 | ||
Migraine with aura | DBP | 0.15 | 1.90 × 10−05 | 0.008 | 0.002 | |
SBP | 0.10 | 2.57 × 10−03 | 0.006 | 0.002 | ||
PP | 0.03 | 0.33 | 0.002 | 0.002 | ||
Migraine without aura | DBP | 0.13 | 1.86 × 10−04 | 0.008 | 0.002 | |
SBP | −0.02 | 0.66 | −0.001 | 0.002 | ||
PP | −0.12 | 2.12 × 10−04 | −0.006 | 0.002 |
rg Genetic correlation, gcov genetic covariance, gcov_se standard error of genetic covariance, LDSC LD score regression, GNOVA genetic covariance analyzer, DBP diastolic blood pressure, SBP systolic blood pressure, PP pulse pressure.
*P-value was calculated for the genetic correlation in LDSC and for the genetic covariance in GNOVA, P-values are based on two-sided Wald test.