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. 2020 Jul 6;10:11047. doi: 10.1038/s41598-020-68110-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proposed mechanism for GPR40 influence in hypothalamic neurogenesis. The synthetic GPR40 ligands increase P38 phosphorylation and BDNF gene expression. Disruption of P38/BDNF signaling impaired the response on hypothalamic neural precursor cells proliferation and differentiation, indicating its involvement in the mechanism of GPR40-induced hypothalamic neurogenesis. 3V third ventricle, Arc arcuate nucleus, BDNF brain derived neurotrophic factor, GPR40 G protein coupled receptor 40 or free fatty acid receptor 1, P38 P38 mitogen-activated protein kinase, TF unknown transcription factor.