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. 2020 Jul 6;6:13. doi: 10.1038/s41531-020-0115-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Percent change (µ ± 2 × s.e.m.) in PDQ-39SI after unilateral DBS (a), after the first lead of staged bilateral DBS (b), and after the second lead of staged bilateral DBS (c) of the GPi (blue) or STN (black). The number of patients included in each data point across time is listed at the bottom of each graph. For visualization purposes, bins with less than five data points are removed. Blue (GPi) or black (STN) stars (*p < 0.05; **p < 0.01) represent significant improvements in PDQ scores compared to baseline values, whereas gray stars with a line underneath represent significant differences between the STN and GPi at the specified time point. If a target was not significant within the mixed model, STN and GPi were pooled together, and compared to baseline, represented by a gray star without a line (*p < 0.05; **p < 0.01). These values were corrected for multiple comparisons using false discovery rate correction.