FIGURE 11.
(A) Top: structure of PCN-333 composed of aluminum trimeric cluster and 4,4′,4″-s-triazine-2,4,6-triyl-tribenzoic acid (TATB) ligand. Bottom: two types of mesoporous cavities in PCN-33 (purple: 4.2 nm, green: 5.5 nm), TYR with size of 5.5 × 5.5 × 5.6 nm3, which can only be accommodated in the 5.5 nm cage. (B) Nontoxic prodrug APAP oxidation is catalyzed by TYR to yield cytotoxic AOBQ, which induces ROS generation and GSH depletion. (C) Time-dependent relative tumor growth upon different treatments. Reproduced from Lian et al. (2018) with permission from Wiley Online Library, copyright 2018.