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. 2020 Jul 6;10:11069. doi: 10.1038/s41598-020-68051-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Change of fatigue measured by FSS. Change of FSS after 6 months of treatment with nusinersen (a). Change of FSS after 10 months of treatment with nusinersen (b). Each bar represents the percentage of patients that had improved to this extent. Dotted lines represent the kernel of distribution. “I” represents median, “diamond” represents mean value, bottom and top edges of the box: Interquartile range (IQR); bottom and top edges of the whiskers: 1.5*IQR.