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Preclinical trials using FAK inhibitors in combination with immunomodulating antibodies.
| Cancer | Inhibitor | Target | References |
|---|---|---|---|
| Breast | PF-573228 | FAK inhibitor | 61 |
| Atezolizumab | Anti-PD-L1 antagonistic antibody | ||
| Pancreatic | VS-4718 | FAK inhibitor | 30 |
| Antagonistic antibodies | Anti-PD1 and Anti-CTLA4 | ||
| Pancreatic and skin | BI 853520 | FAK inhibitor | 31 |
| Anti-OX-40 or anti-4-IBB antibodies | CD8+ T cell activator | ||
| Gemcitabine | Blocks DNA replication |
