Table 2.

Multiple regression analysis of B12 with BMI in early pregnancy.

BMI*	Cohort 1			Cohort 2
	Β	95% CI	p	Β	95% CI	p
Model 1
B12*	− 0.237	(− 0.377, − 0.097)	0.001	− 0.564	(− 0.787, − 0.314)	< 0.0001
Model 2
Age	0.017	(− 0.011, 0.046)	0.229	− 0.033	(− 0.068, 0.001)	0.059
Smoking	− 0.191	(− 0.542, 0.161)	0.287	0.003	(− 0.266, 0.273)	0.980
Alcohol	0.264	(− 0.047, 0.575)	0.096	− 0.002	(− 0.030, 0.025)	0.855
Parity	0.138	(− 0.167, 0.444)	0.372	0.196	(− 0.043, 0.436)	0.0106
Socio-economic status	0.045	(− 0.066, 0.155)	0.426	0.404	(0.293, 0.515)	< 0.0001
B12*	− 0.187	(− 0.358, − 0.016)	0.032	− 0.185	(− 0.377, 0.007)	0.059
Folate*	− 0.002	(− 0.162, 0.158)	0.982	0.142	(− 0.090, 0.374)	0.222
Model 3
Age	0.018	(− 0.010, 0.047)	0.205	− 0.020	(− 0.058, 0.018)	0.300
Smoking	− 0.201	(− 0.559, 0.156)	0.268	0.016	(− 0.299, 0.331)	0.918
Alcohol	0.210	(− 0.107, 0.526)	0.193	− 0.006	(− 0.034, 0.022)	0.683
Parity	0.145	(− 0.160, 0.451)	0.350	0.208	(− 0.036, 0.452)	0.092
Socio-economic status	0.069	(− 0.046, 0.183)	0.239	0.372	(0.245, 0.499)	< 0.0001
B12*	− 0.260	(− 0.440, − 0.079)	0.005	− 0.220	(− 0.424, − 0.016)	0.036
Folate*	− 0.008	(− 0.175, 0.158)	0.923	0.102	(− 0.156, 0.360)	0.427
Homocysteine*	− 0.054	(− 0.221, 0.112)	0.521	0.022	(− 0.223, 0.268)	0.853
MMA*	− 0.177	(− 0.363, 0.010)	0.064	− 0.171	(− 0.359, 0.016)	0.072
Methionine*	0.123	(− 0.093, 0.339)	0.263	0.100	(− 0.098, 0.299)	0.312
SAM*	0.145	(− 0.012, 0.303)	0.070	0.056	(− 0.110, 0.222)	0.500
SAH*	0.015	(− 0.175, 0.205)	0.877	0.072	(− 0.114, 0.258)	0.436

*Log transformed for statistical comparisons, β represents SDS change in the dependent variable per SDS change in the independent variable. SAM—S-adenosyl methionine, SAH—S-adenosyl homocysteine, MMA—Methyl malonic acid.

Model 1: Unadjusted.

Model 2: Model 1 + Adjusted for age, smoking, alcohol, parity, socio-economic status, B12, folate.

Model 3: Model 2 + Adjusted for homocysteine, MMA, methionine, SAM and SAH.