Table 3.
Univariate analysis and multivariate analysis of prognostic factors for overall survival using Cox proportional hazards regression model (N = 97).
| Variables | Univariate analysis | Multivariate analysis | Multivariate analysis | Multivariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | |
|
Gender Male vs female |
1.047 (0.529–2.073) | 0.895 | 1.132 (0.557–2.300) | 0.733 | 1.385 (0.693–2.768) | 0.356 | 1.427 (0.708–2.874) | 0.032 | 1.835 (0.889–3.787) | 0.101 |
|
Age ≤45 vs >45 |
0.643 (0.359–1.042) | 0.126 | 2.084 (0.989–4.393) | 0.054 | 1.918 (0.916–4.018) | 0.084 | 1.958 (0.937–4.094) | 0.074 | 1.905 (0.912–3.979) | 0.086 |
|
Primary T stage T1–2 vs T3–4 |
2.420 (1.296–4.520) | 0.006b | 1.153 (0.574–2.315) | 0.689 | 0.965 (0.474–1.963) | 0.921 | 1.068 (0.530–2.155) | 0.139 | 1.163 (0.579–2.334) | 0.671 |
| Lymph node (N) metastasis | 1.582 (0.781–3.204) | 0.203 | 0.404 (0.170–0.959) | 0.040a | 0.423 (0.178–1.005) | 0.051 | 0.658 (0.296–1.461) | 0.304 | 0.550 (0.247–1.226) | 0.144 |
| TNM stage | 0.143 (0. 044–0.462) | 0.001b | 8.530 (11.917–37.960) | 0.005b | 9.349 (2.098–41.671) | 0.003b | 5.425 (1.284–22.914) | 0.021a | 6.796 (1.635–28.251) | 0.008b |
|
MiR-450b-5p high vs low |
0.227 (0.112–0.462) | 0.000c | 0.231 (0.109–0.448) | 0.000c | / | / | / | / | / | / |
|
RKIP high vs low |
0.317 (0.160–0.628) | 0.001b | / | / | 0.355 (0.172–0.735) | 0.005b | / | / | / | / |
|
NRF2 high vs low |
4.214 (2.076–8.553) | 0.000c | / | / | / | / | 2.747 (1.312–5.751) | 0.007b | / | / |
|
NQO1 high vs low |
3.165 (1.597–6.272) | 0.001b | / | / | // | / | / | / | 2.674 (1.302–5.491) | 0.007b |
HR hazard ratio, 95% CI, 95% confidence interval.
aP < 0.05.
bP < 0.01.
cP < 0.001.