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. 2020 Jun 30;11:660. doi: 10.3389/fphys.2020.00660

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Copyright © 2020 Smith, Roy, Cleveland, Mattson, Okamura, Charlebois, Hamlington, Novotny, Knudsen, Ochs, Hite and Bates.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative micrographs for control (first row) and VILI (second row) mice that were perfusion fixed at an airway pressure Paw = 2 cmH₂O (first column), Paw = 5 cmH₂O (second column), and Paw = 10 cmH₂O (third column). Asterisk indicates alveolar edema and arrows denote retracted alveolar septa.