TABLE 3.
Summarized stereological data from control and VILI lungs.
| Paw cmH2O | V(alvair) ml | V(ductair) ml | V(edema) ml | V(sep,air) ml | V(sep,total) ml | S(alvair) cm2 | τ (sep) μm | N(alv) | N(flood) | N(alv,total) | Vn(alv) μm3 |
| Control | |||||||||||
| 2 | 0.166%,&,* (0.016) | 0.089%,& (0.007) | 0.000* (0.000) | 0.101* (0.019) | 0.116 (0.016) | 260.6%,&,* (30.4) | 7.8 (1.1) | 2,416,000* (110,815) | 0* (0) | 2,416,000* (110,815) | 68,660& (10,074) |
| 5 | 0.272#,&,* (0.037) | 0.161#,& (0.024) | 0.002* (0.002) | 0.105* (0.025) | 0.107 (0.025) | 352.3#,&,* (47.4) | 5.9 (0.7) | 2,632,000* (431,010) | 0* (0) | 2,632,000 (431,010) | 101,420& (25,039) |
| 10 | 0.421#,%,* (0.038) | 0.316#,% (0.032) | 0.002* (0.002) | 0.118* (0.008) | 0.120 (0.007) | 431.1#,%,* (29.1) | 5.5 (0.3) | 2,510,000* (140,712) | 0* (0) | 2,510,000 (140,712) | 168,200#,%,* (8,106) |
| VILI | |||||||||||
| 2 | 0.052%,&,* (0.016) | 0.075%,& (0.013) | 0.043* (0.011) | 0.040* (0.009) | 0.099 (0.015) | 116.1%,&,* (24.0) | 6.9 (0.5) | 991,800%,&,* (182,486) | 312,020* (178,976) | 1,294,000%,&,* (202,745) | 52,540& (11,141) |
| 5 | 0.158#,&,* (0.011) | 0.196#,& (0.022) | 0.045* (0.022) | 0.062* (0.027) | 0.088 (0.023) | 210.5#,&,* (14.1) | 5.8 (2.2) | 1,976,000#,* (184,201) | 412,200* (122,873) | 2,386,800# (235,812) | 79,540& (9,362) |
| 10 | 0.243#,%,* (0.022) | 0.357#,% (0.027) | 0.050* (0.006) | 0.075* (0.015) | 0.105 (0.017) | 278.4#,%,* (39.0) | 5.4 (1.2) | 2,024,000#,* (259,962) | 400,400* (81,048) | 2,423,400# (247,958) | 123,520#,%,* (26,696) |
Lungs were perfusion fixed at airway pressures Paw = 2, 5, and 10 cmH2O. Values are given as mean (standard deviation). Significant differences from Paw = 2 cmH2O (#), Paw = 5 cmH2O (%), Paw = 10 cmH2O (&) in the same treatment group. Significant difference at the same airway pressure between treatment groups is shown with asterisks. Each pressure in control and VILI includes n = 5 mice.