Table 1.
Ratio of concentration fluctuations in the serum metabolite markers (n = 61) best describing the detected variation and metabolic recovery of the athletes within 48 h post-marathon.
| Compound name (PubChem ID) | PM/PrM ratio | D1/PM ratio | D2/PM ratio | D2/D1 ratio | D1/PrM ratio | D2/PrM ratio |
|---|---|---|---|---|---|---|
| Carbohydrate and associated intermediates | ||||||
| Arabitol (439255) | 1.36* | 0.75* | 0.65* | 0.87 | 1.01 | 0.88 |
| Erythritol (222285) | 1.77* | 0.61* | 0.39* | 0.63 | 1.08 | 0.68 |
| Glucose (5793) | 8.91* | 0.17* | 0.09* | 0.52 | 1.48 | 0.77 |
| Mannitol (6251) | 1.34 | 0.78 | 0.58* | 0.75 | 1.05 | 0.78 |
| Mannose (18950) | 15.72* | 0.11* | 0.05* | 0.49 | 1.66 | 0.82 |
| Myo-inositol (440194) | 1.10 | 0.76* | 0.63* | 0.82 | 0.84 | 0.69 |
| Psicose (441036) | 1.15 | 0.45* | 0.70 | 1.56 | 0.52 | 0.80 |
| Rhamnose (5460029) | 0.62* | 1.51 | 1.86* | 1.23 | 0.94 | 1.16 |
| Ribose (10975657) | 1.16 | 0.58* | 0.89 | 1.53 | 0.67 | 1.03 |
| Sorbose (439192) | 1.46 | 0.69 | 0.64* | 0.94 | 1.01 | 0.94 |
| Tagatose (439312) | 1.87* | 0.56* | 0.53* | 0.95 | 1.04 | 0.99 |
| Talose (441035) | 1.69* | 0.57* | 0.52* | 0.91 | 0.96 | 0.87 |
| Threonic acid (151152) | 1.39* | 0.80* | 0.78* | 0.98 | 1.11 | 1.09 |
| Uridine (6029) | 1.06 | 0.61* | 1.02 | 1.66* | 0.65 | 1.08 |
| Xylose (135191) | 0.90 | 0.52* | 0.76 | 1.45 | 0.47* | 0.69 |
| Lipid and associated intermediates | ||||||
| α-Hydroxyoctanoic acid (94180) | 1.49* | 0.63* | 0.67 | 1.06 | 0.94 | 0.99 |
| α-Linolenic acid (5280934) | 1.26* | 0.69* | 0.74* | 1.07 | 0.87 | 0.93 |
| β-Hydroxyhexanoic acid (11829482) | 3.00* | 0.38* | 0.31* | 0.82 | 1.13 | 0.92 |
| 5-Dodecenoic acid (5312377) | 35.22* | 0.02* | 0.06* | 3.73 | 0.59 | 2.19 |
| 10-Heptadecenoic acid (5312434) | 5.87* | 0.12* | 0.15* | 1.22 | 0.73 | 0.89 |
| 11,14-Eicosadienoic acid (5282805) | 1.94* | 0.54* | 0.45* | 0.83 | 1.05 | 0.87 |
| 11-Eicosenoic acid (5282768) | 3.48* | 0.31* | 0.37* | 1.20 | 1.06 | 1.28 |
| Docosahexaenoic acid (445580) | 1.17 | 0.69* | 0.80 | 1.17 | 0.80 | 0.94 |
| Eicosapentaenoic acid (446284) | 1.30 | 0.69* | 0.74* | 1.07 | 0.90 | 0.96 |
| Glycerol (753) | 5.84* | 0.17* | 0.19* | 1.11 | 0.99 | 1.10 |
| Glycerol monopalmitic acid (308463) | 1.87* | 0.44* | 0.55* | 1.24 | 0.82 | 1.02 |
| Heptadecanoic acid (10465) | 1.82* | 0.52* | 0.52* | 1.01 | 0.94 | 0.95 |
| Lauric acid (3893) | 2.07* | 0.57* | 0.46* | 0.81 | 1.17 | 0.95 |
| Methyl oleic acid (9922235) | 1.68* | 0.48* | 0.72 | 1.51 | 0.81 | 1.22 |
| Myristoleic acid (5281119) | 12.33* | 0.06* | 0.08* | 1.32 | 0.70 | 0.93 |
| Oleic acid (445639) | 5.04* | 0.21* | 0.22* | 1.07 | 1.06 | 1.13 |
| Palmitic acid (985) | 1.67* | 0.55* | 0.57* | 1.04 | 0.93 | 0.96 |
| Palmitoleic acid (445638) | 6.26* | 0.19* | 0.22 | 1.17 | 1.20 | 1.40 |
| Pentadecanoic acid (13849) | 2.21* | 0.51* | 0.43* | 0.85 | 1.13 | 0.96 |
| Ketones and TCA cycle intermediates | ||||||
| α-Ketoglutaric acid (51) | 1.57* | 0.58* | 0.64* | 1.11 | 0.91 | 1.01 |
| β-Hydroxybutyric acid (441) | 12.98* | 0.06* | 0.06* | 1.12 | 0.72 | 0.81 |
| Acetoacetic acid (96) | 2.89 | 0.37* | 0.19* | 0.51 | 1.07 | 0.54 |
| Citric acid (311) | 1.46 | 0.74 | 0.58* | 0.78 | 1.08 | 0.85 |
| Fumaric acid (444972) | 1.42 | 0.75 | 0.68* | 0.91 | 1.06 | 0.96 |
| Malic acid (525) | 1.62* | 0.57* | 0.52* | 0.90 | 0.93 | 0.84 |
| Malonic acid (867) | 1.37 | 0.72 | 0.62* | 0.86 | 0.99 | 0.85 |
| Amino acid and cholesterol-associated intermediates | ||||||
| α-Ethylhydracrylic acid (188979) | 2.24* | 0.48* | 0.47* | 0.97 | 1.08 | 1.05 |
| α-Hydroxybutyric acid (11266) | 2.53* | 0.52* | 0.49* | 0.93 | 1.31 | 1.23 |
| β-Hydroxyisobutyric acid (87) | 15.39* | 0.04* | 0.06* | 1.29 | 0.67 | 0.87 |
| β-Hydroxyisovaleric acid (69362) | 1.15 | 0.89 | 0.75* | 0.84 | 1.02 | 0.86 |
| 5-Pregnen-3β,20α-diol (312224064) | 1.93* | 0.38* | 0.36* | 0.96 | 0.73 | 0.70 |
| Alanine (5950) | 0.64 | 2.34* | 1.86* | 0.79 | 1.51 | 1.19 |
| Aminomalonic acid (100714) | 0.48 | 2.10* | 2.06* | 0.98 | 1.01 | 0.99 |
| Aspartic acid (5960) | 0.60 | 2.03* | 1.36 | 0.67 | 1.22 | 0.82 |
| Glutamic acid (33032) | 0.79 | 1.51* | 1.39 | 0.92 | 1.19 | 1.10 |
| Glutaric acid (743) | 1.73 | 1.12 | 0.52* | 0.46 | 1.94 | 0.89 |
| Glycine (750) | 0.59 | 1.79* | 1.45 | 0.81 | 1.06 | 0.86 |
| Hydroxyproline (5810) | 0.44 | 2.03 | 2.68* | 1.32 | 0.89 | 1.18 |
| Methionine (6137) | 0.54 | 2.17* | 1.88* | 0.87 | 1.18 | 1.02 |
| Phenylalanine (6140) | 0.64 | 1.93* | 1.47* | 0.76 | 1.24 | 0.95 |
| p-Hydroxyphenylacetic acid (127) | 2.00 | 0.51* | 0.45* | 0.88 | 1.03 | 0.90 |
| p-Hydroxyphenyllactic acid (9378) | 1.53 | 0.66* | 0.58* | 0.88 | 1.01 | 0.89 |
| Pyroglutamic acid (7405) | 0.71* | 1.35* | 1.41* | 1.04 | 0.95 | 1.00 |
| Squalene (638072) | 3.39* | 0.31* | 0.34* | 1.07 | 1.06 | 1.14 |
| Tyrosine (6057) | 0.64 | 1.78* | 1.57* | 0.88 | 1.14 | 1.01 |
| Valine (6287) | 0.53 | 1.83 | 2.21* | 1.21 | 0.97 | 1.18 |
PrM Pre-marathon, PM Post-marathon, D1 24 h post-marathon, D2 48 h post-marathon.
Significant p-and d-values (*).