Table 3.
MiRNAs that modulate drug chemoresistance through intracellular mechanisms.
| MiRNA | Target | Mechanism | MiRNA regulated mechanism | Drug | References |
|---|---|---|---|---|---|
| MiR-223 | ABCB1 | Membrane transporter | Negatively | Doxorubicin | (51) |
| MiR-27a | MDR1, β-catenin | Membrane transporter | Negatively | 5-FU | (52) |
| MiR-133/326 | ABCC1 | Membrane transporter | Negatively | Doxorubicin | (57) |
| MiR-379 | ABCC2 | Membrane transporter | Negatively | (58) | |
| MiR-338-3p | HIF-1α | Hypoxia | Negatively | Sorafenib | (94) |
| MiR-125b | HK II | Warburg effect | Negatively | 5-FU | (104) |
| MiR-122 | PDK4 | CSC, Warburg effect | Negatively | (105) | |
| MiR-342-3p | IGF-1R | Warburg effect | Negatively | (102) | |
| MiR-539 | Bcl-2, Bcl-xL, Stat3 | Apoptosis | Negatively | (110) | |
| MiR-34a | Bcl-2 | Apoptosis | Negatively | Sorafenib | (111) |
| MiR-363 | Mcl-1 | Apoptosis | Negatively | Cisplatin | (112) |
| MiR-25 | PTEN/PI3K/AKT/Bad | CSC, apoptosis | Negatively | TRAIL | (88) |
| MiR-19a-3p | PTEN/AKT | Apoptosis | Negatively | Sorafenib | (118) |
| MiR-216a/217 | PTEN, Smad7 | Apoptosis | Negatively | Sorafenib | (119) |
| MiR-205-5p | PTEN/JNK/ANXA3 | Apoptosis | Negatively | 5-FU | (120) |
| MiR-760 | Notch1 | Apoptosis | Negatively | Doxorubicin | (121) |
| MiR-622 | KRAS | Apoptosis | Negatively | Sorafenib | (124) |
| Let-7g | KRAS | Apoptosis | Negatively | (125) |
miRNAs, microRNAs; 5-FU, 5-fluorouracil; CSC, cancer stem cell; PTEN, phosphatase and tensin homolog deleted on chromosome 10.