Table 4.
MiRNAs that modulate drug chemoresistance through extracellular mechanisms.
| MiRNA | Target | Mechanism | MiRNA regulated mechanism | Drug | References |
|---|---|---|---|---|---|
| MiR-200c | E-cadherin, Zeb1/2 | EMT | Negatively | Anti-EGFR | (69) |
| MiR-130a-3p | Smad4 | EMT | Negatively | Gemcitabine | (70) |
| MiR-106a | PDGF-D, Twist1 | EMT | Negatively | Gemcitabine | (71) |
| MiR-122 | Zeb1/2, Snail1/2 | EMT | Negatively | (72) | |
| MiR-153 | Snail | EMT | Negatively | (73) | |
| Let-7a | Wnt | CSC | Negatively | (87) | |
| MiR-25 | PTEN/PI3K/AKT/Bad | CSC, apoptosis | Negatively | TRAIL | (88) |
| MiR-148b | NRP1 | CSC | Negatively | (89) | |
| MiR-125b | Smad2/4 | CSC, EMT | Negatively | (90) |
EMT, epithelial–mesenchymal transition; CSC, cancer stem cell; PTEN, phosphatase and tensin homolog deleted on chromosome 10.