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. 2020 Jun 30;11:596. doi: 10.3389/fphys.2020.00596

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Copyright © 2020 Jiang, Yang, Zhang, Song, Liu and Lv.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EX527 blunted GYY4137-induced pulmonary protective effect on lung IR injury in type 2 diabetic rats. (A) Arterial blood gas analysis. T0–T7 represent the following time points: baseline, end of ischemia, and 30, 60, 90, 120, 180, and 240 min after reperfusion. (B) Static compliance of the lung pressure–volume (P–V) curves. Data are represented by the mean values, and the bars are omitted for clarity. (C) Histologic analysis of lung tissues. (magnification: 200×). (D) Lung injury score. (E) Wet/dry weight ratio. (F) Survival analysis. Rats were observed for 168 h (1 week), and survival time was calculated. (G) Lung H₂S levels in rat (^cP < 0.05 versus DM + sham group/^ccP < 0.01 versus DM + sham group, ^dP < 0.05 versus DM + IR group/^ddP < 0.01 versus DM + IR group, ^eP < 0.05 versus DM + IR + H group/^eeP < 0.01 versus DM + IR + H group; n = 8 in each group).