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. 2020 Jun 30;11:596. doi: 10.3389/fphys.2020.00596

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Copyright © 2020 Jiang, Yang, Zhang, Song, Liu and Lv.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EX527 attenuated GYY4137-induced alleviation of the inflammation in diabetic lung IR injury. (A) Serum concentrations of interleukin-6 (IL-6). (B) TNF-α. (C) MPO concentration. (D) Representative lung immunohistochemical images of SIRT1 (magnification: 200×). (E) Representative blots. (F) SIRT1 expression. (G) The ratio of p-eNOS/eNOS. (H) mRNA expression of SIRT1 (n = 4). (I) Relative SIRT1 activity. (J) Representative blots. (K) Ac-eNOS. (L) Biotin switch assay. (M) Sulfhydrated SIRT1 expression. Ac-eNOS, acetylated endothelial nitric oxide synthase; eNOS, endothelial nitric oxide synthase; p-eNOS, phosphorylated endothelial nitric oxide synthase (^ccP < 0.01 versus DM + sham group, ^ddP < 0.01 versus DM + IR group, ^eP < 0.05 versus DM + IR + H group/^eeP < 0.01 versus DM + IR + H group; n = 8 in each group).