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DC differentiation and maturation. DC precursors are differentiating into immature DC. Immature DCs are activated with specific stimuli, TNF-α, CD40L, IL-6, IFN-γ, PAMPs, DAMPs promote DC maturation, corresponding to Th1 or Th2 cells priming. DCs stimulate with TGF-β, IL-10 present tolerogenic phenotype leading to Treg differentiation. Immature DC decorated with type I IFN, IL-12 and IL-15 favor NK cell function.
