TABLE 5.
Brain regions exhibiting a significant negative correlation between MMSE score and regional brain uptakes of [18F]-APN-1607 in AD group (P < 0.01, uncorrected).
| Region* | Hemisphere | Cluster size (mm3) | Z Max | Coordinates† |
||
| X | Y | Z | ||||
| Superior frontal gyrus (BA 10)‡ | Right | 91,784 | 3.65 | 16 | 60 | −16 |
| Middle frontal gyrus (BA 10)‡ | Right | 91,784 | 3.43 | 36 | 52 | −16 |
| Middle frontal gyrus (BA 9)‡ | Right | 91,784 | 3.24 | 38 | 36 | 28 |
| Middle temporal gyrus (BA 21) | Right | 19,376 | 3.00 | 68 | −28 | −10 |
| Parahippocampal gyrus (BA 36) | Right | 19,376 | 2.95 | 34 | −34 | −12 |
| Lentiform nucleus (lateral globus pallidus) | Right | 19,376 | 2.89 | 28 | −12 | −12 |
| Middle frontal gyrus (BA 10) | Left | 20,664 | 2.98 | −30 | 54 | −16 |
| Middle frontal gyrus (BA 47) | Left | 20,664 | 2.90 | −46 | 38 | −10 |
| Middle frontal gyrus (BA 11) | Left | 20,664 | 2.87 | −26 | 34 | −20 |
*Significant at uncorrected voxel threshold of P < 0.01, extent threshold = 937 voxels (7,504 mm3). †Coordinates are displayed in MNI standard space. ‡Survived at FWE-corrected voxel threshold of P < 0.05. BA, Brodmann area; FWE, familywise error.