TABLE 6.
Summary of ROI analyses of different tau tracers in AD and NC groups.
| Cohorts | NC | AD | Cohen d | ||
| [18F]-AV-1451 (Shcherbinin et al., 2016) | AD N = 5, MMSE = 21.8 (4.1) NC N = 5, MMSE = MMSE = 29.6 (0.5) | Frontal | 1.00 (0.16) | 1.65 (0.69) | 1.30 |
| Occipital | 1.07 (0.18) | 1.67 (0.59) | 1.38 | ||
| Lateral parietal | 1.05 (0.19) | 2.03 (0.84) | 1.61 | ||
| Mesial temporal | 1.09 (0.14) | 1.78 (0.48) | 1.95 | ||
| Lateral temporal | 1.10 (0.15) | 2.15 (0.89) | 1.65 | ||
| Putamen | 1.34 (0.09) | 1.78 (0.23) | 2.52 | ||
| [18F]-THK5351 (Kang et al., 2017) | AD N = 51, MMSE = 13.8 (6.0) NC N = 43, MMSE = 28.5 (1.6) | Frontal | 1.35 (0.22) | 2.05 (0.34) | 2.44 |
| Occipital | 1.09 (0.15) | 1.57 (0.46) | 1.40 | ||
| Superior parietal | 1.18 (0.20) | 1.80 (0.43) | 1.85 | ||
| Inferior parietal | 1.34 (0.21) | 2.60 (0.69) | 2.47 | ||
| Lateral temporal | 1.60 (0.23) | 2.71 (0.49) | 2.90 | ||
| Mesial temporal | 2.42 (0.27) | 3.52 (0.59) | 2.40 | ||
| Anterior cingulate | 2.88 (0.43) | 3.40 (0.57) | 1.03 | ||
| Hippocampus | 2.44 (0.27) | 3.40 (0.55) | 2.22 | ||
| Fusiform | 1.51 (0.19) | 2.39 (0.57) | 2.07 | ||
| Entorhinal | 2.15 (0.34) | 3.36 (0.89) | 1.80 | ||
| Basal ganglia | 3.08 (0.48) | 3.72 (0.62) | 1.15 | ||
| [11C]-PBB3 (Kitamura et al., 2018) | AD/MCI N = 7, MMSE = 23.7 (6.9) NC N = 9, MMSE = 29.4 (0.7) | Frontal | 0.86 (0.04) | 0.94 (0.09) | 1.15 |
| Occipital | 0.90 (0.03) | 1.05 (0.07) | 2.79 | ||
| Parietal | 0.83 (0.05) | 0.97 (0.09) | 1.92 | ||
| Medial temporal | 0.99 (0.05) | 1.02 (0.05) | 0.60 | ||
| Lateral temporal | 0.95 (0.04) | 1.05 (0.06) | 1.96 | ||
| Anterior cingulate | 0.91 (0.07) | 0.94 (0.01) | 0.60 | ||
| [18F]-MK6240 (Lohith et al., 2019) | AD N = 4, MMSE = 16.5 (7.3) NC N = 4, MMSE = 29.0 (0.0) | Temporal | 0.98 (0.07) | 1.64 (0.72) | 1.29 |
| Hippocampus | 0.93 (0.10) | 1.37 (0.25) | 2.31 | ||
| Amygdala | 0.84 (0.11) | 1.67 (0.40) | 2.83 | ||
| Caudate | 0.79 (0.06) | 0.71 (0.16) | 0.66 | ||
| Putamen | 0.91 (0.04) | 1.15 (0.35) | 0.96 | ||
| [18F]-RO948 (Wong et al., 2018) | AD N = 11, MMSE = 20.8 (2.7) NC N = 5) | Middle frontal lobe | 1.13 (0.10) | 2.27 (1.40) | 1.15 |
| Lateral occipital lobe | 1.35 (0.10) | 2.34 (1.30) | 1.07 | ||
| Precuneus | 1.16 (0.20) | 2.29 (1.50) | 1.06 | ||
| Superior parietal | 1.24 (0.10) | 2.18 (1.10) | 1.20 | ||
| Inferior parietal | 1.32 (0.10) | 2.8 (1.50) | 1.39 | ||
| Inferior temporal | 1.14 (0.10) | 2.75 (1.40) | 1.62 | ||
| Middle temporal | 1.15 (0.10) | 2.54 (1.40) | 1.40 | ||
| Posterior cingulate | 1.1 (0.10) | 1.96 (1.20) | 1.01 | ||
| Insula | 0.98 (0.10) | 1.46 (0.50) | 1.33 | ||
| Hippocampus | 0.90 (0.20) | 1.26 (0.30) | 1.40 | ||
| Parahippocampus | 0.96 (0.10) | 1.95 (0.70) | 1.97 | ||
| Amygdala | 0.81 (0.10) | 1.72 (0.70) | 1.83 | ||
| Caudate | 0.80 (0.10) | 0.97 (0.20) | 1.06 | ||
| Putamen | 0.93 (0.10) | 1.28 (0.20) | 2.24 | ||
| Thalamus | 0.90 (0.10) | 1.00 (0.20) | 0.69 | ||
| [18F]-PI2620 (Mueller et al., 2019) | AD N = 12, MMSE = 20.4 (6.3) NC N = 10, MMSE = 29.0 (1.2) | Occipital | 1.08 (0.08) | 1.45 (0.23) | 2.15 |
| Parietal | 1.03 (0.06) | 1.53 (0.40) | 1.75 | ||
| Superior temporal | 1.07 (0.10) | 1.36 (0.23) | 1.64 | ||
| Inferior temporal | 1.09 (0.10) | 1.80 (0.40) | 2.44 | ||
| Posterior cingulate | 1.03 (0.13) | 1.82 (0.68) | 1.61 | ||
| Hippocampus | 1.07 (0.08) | 1.26 (0.20) | 1.25 | ||
| Parahippocampus | 1.07 (0.11) | 1.46 (0.29) | 1.78 | ||
| Amygdala | 0.99 (0.11) | 1.29 (0.29) | 1.37 | ||
| Fusiform | 1.07 (0.11) | 1.63 (0.29) | 2.55 | ||
| Striatum | 0.83 (0.1) | 1.02 (0.14) | 1.56 | ||
| Pallidum | 0.95 (0.17) | 1.10 (0.14) | 0.96 | ||
| Thalamus | 0.93 (0.11) | 0.96 (0.07) | 0.33 |
AD, Alzheimer’s disease; NC, normal control.