Table 2.

APJ-S339A mutation impairs the receptor's interactions with GRK2 and β-arrestins via apelin-36 stimulation.

	EC50 (nM)
	GRK2	β-Arrestin1	β-Arrestin2
APJ WT	5.33 ± 0.63	4.54 ± 0.52	5.18 ± 0.65
APJ S-335A	5.89 ± 0.80	4.5 ± 0.40	5.01 ± 0.45
APJ S-339A	9.91 ± 1.54	9.72 ± 0.85	8.74 ± 1.02
APJ S-345A	5.62 ± 0.86	4.36 ± 0.48	5.24 ± 0.43
APJ S-348A	4.82 ± 0.47	4.95 ± 0.36	4.98 ± 0.63
APJ S-369A	5.04 ± 0.76	4.99 ± 0.45	4.89 ± 0.46