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. 2020 Jun 30;11:1158. doi: 10.3389/fimmu.2020.01158

Figure 1.

Figure 1

Dysregulated homeostasis in both immune cells and exocrine glands is involved in the development of SS-like disease in mice. On the one hand, abnormal proliferation (HLV1-tax-Tg model), apoptosis of exocrine gland epithelial cells (STAT3 KO, IκB-ζ KO, NOD-derived mice, NFS/sld, TSP-1 KO, Ar KO, and RbAp48-tg mouse models), and ectopic expression of MHC II in the exocrine gland (IQI/Jic, Ro60-peptide immunization, RbAp48-tg, and M3R-immunized models) are suggested to be involved in disease pathogenesis by the corresponding mouse models. On the other hand, APCs (TSP1 KO), CD4 T cells (Aly/Aly, RbAp48-tg, Ar KO, Act1 KO, PI3K KO, and M3R immunization mouse models), B cells (Ar KO, Act1 KO, NOD, Ro60-peptide immunization, BAFF-tg), Treg cells (Ar KO, NFS/sld, IQI/Jic), and cytokines (SG protein immunization) have been suggested to play a role in the development of disease in corresponding mouse models.