Table 1.
Summary of mouse models of SS.
| Models | Autoantibodies | Infiltration | Secretion Impairment | Ectopic expression of MHC II | Apoptosis of glandular epithelial cells | References | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SSA | SSB | M3R | 120 kD α-fordin | Salivary | Tears | ||||||||
| Genetic models | NOD Jcl/ICR | Yes | Yes | Yes | Yes | Yes | Yes | Pancreas | Yes | Yes | ND | Yes | (18, 19) |
| NOD.B10-H2b | Yes | Yes | Yes | ND | Yes | Yes | ND | Yes | Yes | ND | ND | (20) | |
| C57BL/6.NOD-Aec1Aec2 | Yes | Yes | Yes | ND | Yes | Yes | ND | Yes | Yes | ND | Yes | (21) | |
| NFS/sld | ND | ND | ND | Yes | Yes | Yes | ND | Yes | ND | Yes | Yes | (22–24) | |
| IQI/Jic | ND | ND | ND | Yes | Yes | Yes | Pancreas, kidneys, lungs | ND | ND | Yes | ND | (25) | |
| Aly/Aly mice | ND | ND | ND | ND | Yes | Yes | Liver, pancreas, lungs | ND | ND | ND | ND | (26) | |
| Ar KO mice | ND | ND | ND | Yes | Yes | ND | Kidney | ND | ND | ND | Yes | (27) | |
| RbAp48 transgenic mice | Yes | Yes | ND | Yes | Yes | Yes | ND | Yes | Yes | Yes | Yes | (28) | |
| Id3 KO mice | ND | ND | ND | ND | Yes | Yes | ND | Yes | Yes | ND | ND | (29) | |
| PI3K KO mice | Yes | Yes | ND | ND | Yes | ND | Lungs, liver, intestines | ND | ND | ND | ND | (30) | |
| TSP-1 KO Mice | Yes | Yes | ND | ND | ND | Yes | ND | ND | Yes | ND | Yes | (31) | |
| Act1 KO mice | Yes | Yes | ND | ND | Yes | Yes | Kidneys | ND | ND | ND | ND | (32) | |
| BAFF transgenic mice | N | N | ND | ND | Yes | Yes | Kidneys | Y | ND | ND | ND | (33) | |
| HTLV-1 tax transgenic mice | ND | ND | ND | ND | Yes | Yes | ND | ND | ND | ND | ND | (34) | |
| Induced models | Ro60_480-494 induced model Ro60_274-290 induced model | Yes | Yes | ND | ND | Yes | ND | ND | Yes | N | ND | ND | (35) |
| Ro60_316-335 induced model | Yes | ND | ND | ND | Yes | Yes | ND | ND | Yes | Yes | No | (36, 37) | |
| M3R induced model | ND | ND | Yes | ND | Yes | ND | ND | Yes | ND | ND | Yes | (38) | |
| MCMV induced model | ND | ND | ND | ND | Yes | Yes | ND | Yes | Yes | ND | ND | (39) | |
| CA II induced model | ND | ND | ND | ND | Yes | Yes | Pancreas, kidney | ND | ND | ND | ND | (40) | |
| SG protein induced model | ND | ND | Yes | ND | Yes | N | N | Yes | N | ND | ND | (41) | |
ND, not determined; Yes, presence of the phenotype; No, absence of the phenotype.