Table 1.
Clinical and MRI features for all subjects included in the analysis.
| HS (n = 32) | MS (n = 49) | p-value* | |
|---|---|---|---|
| Clinical variables | |||
| Mean age (SD), years | 33.28 (7.6) | 35.02 (8.1) | n.s. |
| Females/males | 22/10 | 36/13 | n.s. |
| Disease course, RR/SP | - | 34/15 | - |
| Mean disease duration, years (range) | - | 7.87 (6.4) | |
| Median EDSS (range) | - | 2.5 (1.0–5.5) | - |
| Mean 25-FWT, s (SD) | 7.76 (3.1) | - | |
| Mean C-EO, mm (SD) | - | 441.76 (443.2) | - |
| Mean C-EC, mm (SD) | - | 838.98 (845.3) | - |
| MRI variables | |||
| WMV | 417.95 ± 48.2 | 388.81 ± 51.1 | 0.044 |
| GMV | 704.95 ± 60.1 | 624.51± 63.8 | 0.011 |
| LV | - | 8.18 ± 8.1 | - |
| Global cerebellar volume | 119.59 ± 18.5 | 103.30 ± 13.1 | 0.039 |
| Anterior cerebellar volume | 14.98 ± 3.5 | 12.76 ± 2.3 | 0.036 |
| Posterior cerebellar volume | 104.61 ± 15.2 | 90.53 ± 11.8 | 0.034 |
| Lobules I–IV volume | 6.65 ± 1.5 | 5.47 ± 1.1 | 0.031 |
| Lobule V volume | 8.32 ± 2.0 | 7.28 ± 1.2 | 0.042 |
| Lobule VI volume | 19.43 ± 4.5 | 17.44 ± 2.2 | 0.047 |
| Crus I volume | 25.74 ± 5.3 | 22.39 ± 3.3 | 0.028 |
| Crus II volume | 19.06 ± 2.9 | 16.32 ± 2.9 | 0.026 |
| Lobule VIIb volume | 10.35± 1.2 | 8.74 ± 1.6 | 0.023 |
| Lobule VIIIa volume | 11.38 ± 1.3 | 9.74 ± 1.3 | 0.021 |
| Lobule VIIIb volume | 9.14 ± 1.2 | 8.74 ± 0.9 | 0.018 |
| Lobule IX volume | 7.73 ± 1.2 | 6.54 ± 0.9 | 0.015 |
| Lobule X volume | 2.15 ± 0.3 | 1.60 ± 0.3 | 0.013 |
Volumes (in milliliters) are expressed as mean ± SD deviation. C-EO, displacement of body center of pressure with eyes open; C-EC, displacement of body center of pressure with eyes closed; EDSS, Expanded Disability Status Scale; GMV, brain gray matter volume; HS, healthy controls; ICV, intracranial volume; LV, whole brain lesion volume; MS, multiple sclerosis; WMV, brain white matter volume; RR, relapsing remitting; SP, secondary progressive.
*
p-values for HC vs. MS comparison, false discovery rate (FDR) corrected.