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. 2020 Jun 30;8:543. doi: 10.3389/fchem.2020.00543

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Copyright © 2020 Yue, Luo, Liu and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of several major gold complexes on innate immune system. gold compounds can not only promote direct immune cell-mediated destruction, but also synergistic promote the T cell-based anticancer immunity cycle via DC. Gold complexes can induce the activation and proliferation of NK, mast cells, monocytes/macrophages, neutrophils, and release of various inflammatory mediators. Furthermore, gold complexes induce DC maturation and enhance antigen presentation through TLR3 dependent signaling. For detailed description see text. NK cell, natural killer cell; DC, dendritic cell; LPS, lipopolysaccharide; TLR, toll-like receptor; TNF-α, tumor necrosis factor α; IL, interleukin; AuTM, sodium aurothiomalate; GST, gold sodium thiomalate; PKC, protein kinase C; HMGB1, high mobility group box chromosomal protein 1.