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. 2020 Jun 30;11:802. doi: 10.3389/fphys.2020.00802

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Copyright © 2020 Ahmed, Paramasivam, Raj, Kumar, Murugesan and Ramakrishnan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional hubs interconnectivity. The hub network of ATP6V1A hub (green node) and hub 5 (violet node) demonstrating the interconnecting proteins between (red dotted edges) the hubs. The yellow nodes represent the viral protein interacting with the hubs. The viral membrane interacts with host ATP6V1A surface protein that activates the series of proteins leading to benefit viral machinery relating to nsp7 and nsp11. The red highlighting node represents the differentially expressed genes on SARS-CoV2 infection derived from RNA-Seq analysis.