Table 3.
Adjusted average difference () in adiposity marker in offspring at 3 and 18 months of age (pooled data) for 1-unit (ng/mL) increase in maternal pregnancy serum PFAA concentration stratified according to sex obtained from random mixed effects linear regression models.
| Compound (ng/mL) | BMI SDS | Ponderal index SDS | Waist circumference SDS | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Girls () | Boys () | Girls () | Boys () | Girls () | Boys () | ||||
| (95% CI) | (95% CI) | a | (95% CI) | (95% CI) | a | (95% CI) | (95% CI) | a | |
| PFHxS | |||||||||
| Adjustedb | 0.03 (, 0.24) | 0.13 (, 0.60) | 0.70 | 0.02 (, 0.82) | 0.34 (, 0.82) | 0.24 | 0.02 (, 0.22) | (, 0.39) | 0.80 |
| PFOS | |||||||||
| Adjustedb | (, 0.02) | (, 0.02) | 0.84 | (, 0.02) | (, 0.03) | 0.64 | (, 0.01) | (, 0.02) | 0.80 |
| PFOA | |||||||||
| Adjustedb | 0.06 (, 0.14) | 0.03 (, 0.11) | 0.67 | 0.09 (0.004, 0.17) | 0.06 (, 0.13) | 0.58 | (, 0.07) | 0.03 (, 0.11) | 0.40 |
| PFNA | |||||||||
| Adjustedb | 0.26 (0.03, 0.49) | 0.10 (, 0.33) | 0.33 | 0.36 (0.13, 0.59) | 0.13 (, 0.36) | 0.16 | 0.14 (, 0.35) | 0.04 (, 0.25) | 0.52 |
| PFDA | |||||||||
| Adjustedb | 0.58 (, 1.19) | 0.24 (, 0.80) | 0.42 | 1.02 (0.40, 1.64) | 0.25 (, 0.82) | 0.07 | 0.07 (, 0.65) | 0.13 (, 0.64) | 0.89 |
Note: BMI, body mass index; CI, confidence interval; PFDA, perfluorodecanoic acid; PFHxS, perfluorohexane sulfonic acid; PFNA, perfluorononanoic acid; PFOA, perfluorooctanoic acid; PFOS, perfluorooctane sulfonic acid; SDS, standard deviation scores.
Interaction between the compound and sex, tested with the likelihood-ratio test.
Adjusted for maternal age, parity, prepregnancy BMI, prepregnancy , educational level, smoking, visit, and adiposity marker at birth.