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. 2020 Jul 6;128(7):077001. doi: 10.1289/EHP5184

Table 3.

Adjusted average difference (β) in adiposity marker in offspring at 3 and 18 months of age (pooled data) for 1-unit (ng/mL) increase in maternal pregnancy serum PFAA concentration stratified according to sex obtained from random mixed effects linear regression models.

Compound (ng/mL) BMI SDS Ponderal index SDS Waist circumference SDS
Girls (n=275) Boys (n=318) Girls (n=275) Boys (n=318) Girls (n=274) Boys (n=315)
β (95% CI) β (95% CI) pinta β (95% CI) β (95% CI) pinta β (95% CI) β (95% CI) pinta
PFHxS
 Adjustedb 0.03 (0.19, 0.24) 0.13 (0.34, 0.60) 0.70 0.02 (0.14, 0.82) 0.34 (0.14, 0.82) 0.24 0.02 (0.19, 0.22) 0.05 (0.49, 0.39) 0.80
PFOS
 Adjustedb 0.01 (0.04, 0.02) 0.004 (0.03, 0.02) 0.84 0.01 (0.04, 0.02) 0.001 (0.03, 0.03) 0.64 0.01 (0.04, 0.01) 0.01 (0.03, 0.02) 0.80
PFOA
 Adjustedb 0.06 (0.02, 0.14) 0.03 (0.04, 0.11) 0.67 0.09 (0.004, 0.17) 0.06 (0.02, 0.13) 0.58 0.01 (0.09, 0.07) 0.03 (0.04, 0.11) 0.40
PFNA
 Adjustedb 0.26 (0.03, 0.49) 0.10 (0.12, 0.33) 0.33 0.36 (0.13, 0.59) 0.13 (0.10, 0.36) 0.16 0.14 (0.08, 0.35) 0.04 (0.17, 0.25) 0.52
PFDA
 Adjustedb 0.58 (0.03, 1.19) 0.24 (0.31, 0.80) 0.42 1.02 (0.40, 1.64) 0.25 (0.32, 0.82) 0.07 0.07 (0.50, 0.65) 0.13 (0.38, 0.64) 0.89

Note: BMI, body mass index; CI, confidence interval; PFDA, perfluorodecanoic acid; PFHxS, perfluorohexane sulfonic acid; PFNA, perfluorononanoic acid; PFOA, perfluorooctanoic acid; PFOS, perfluorooctane sulfonic acid; SDS, standard deviation scores.

a

Interaction between the compound and sex, tested with the likelihood-ratio test.

b

Adjusted for maternal age, parity, prepregnancy BMI, prepregnancy BMI2, educational level, smoking, visit, and adiposity marker at birth.